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Overview: Blocking this pathway in mice dramatically reduced neurodegeneration and preserved cognitive abilities, pointing to a potentially more accessible treatment target.

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The reductions were still present one year later, with the highest dose lowering LDL by 52.5% and triglycerides by 47.8%.

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The shift could help explain astronaut constipation and may have wider effects on health, making it an important concern for future missions to Mars.

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